"Mutya na Agsam" is an animation that centers on the mythical tale of a magical amulet known as the Mutya na Agsam, which is said to possess the power to control nature and bring prosperity to those who hold it. The agsam, a type of indigenous vine, is a sacred symbol in the remote village where the story takes place.

The protagonist, a young girl named Lira, stumbles upon the Mutya during an exploration of the forest, unaware of its ancient significance. Soon after, her village begins to thrive—crops grow abundantly, animals return to the forests, and the once struggling community experiences prosperity. However, Lira discovers that the Mutya also attracts the attention of dark forces and greedy individuals who want its power for themselves.

As the village is threatened by these malevolent entities, Lira must learn the true responsibility of possessing the Mutya na Agsam. With guidance from local elders and the protective spirits of the forest, she embarks on a journey to safeguard the Mutya and restore balance to her village. The animation weaves themes of nature, responsibility, and the consequences of power, deeply rooted in Filipino folklore.