In the "Guess The Emoji Challenge (Ang Hirap!)" video, Ranz and Niana participate in a fun and interactive game where they have to guess words, phrases, or titles represented by emojis. The challenge involves various rounds, with each round becoming progressively harder. They share laughs and playful banter as they try to decipher the clues, sometimes getting creative with their guesses. The video highlights their competitive spirit and camaraderie, making it an entertaining watch for fans who enjoy emoji games and lighthearted challenges.