The story revolves around a group of passengers on a flight to Las Vegas, which is intended for adults only. Key characters include Karen, a retired schoolteacher who dislikes children; June, her friend; and Cliff, Karen's ex-husband, who is flying with his fiancée, Angelica.

As the flight progresses, tensions arise when it’s discovered that a baby is onboard, violating the flight's age policy. Karen is particularly incensed and attempts to have the baby removed. After a series of humorous misunderstandings and conflicts, the flight is ultimately canceled due to technical issues, forcing the passengers to find alternative arrangements.

Throughout the chaos, Karen's disdain for children and her past with Cliff create comedic situations, leading to confrontations and unexpected alliances. In the end, Karen’s plan to rid the flight of children backfires, resulting in her being asked to leave the flight herself. The story highlights themes of frustration, misunderstanding, and the unpredictability of travel, all wrapped in a lighthearted tone.