In the #WhoKnowsMeBetterChallenge with Vice Ganda, friends and celebrity guests compete to see who knows Vice best. The challenge involves answering personal questions about Vice's preferences, experiences, and quirks. With a mix of laughter and playful teasing, the participants reveal amusing anecdotes and insights about Vice's life. The playful atmosphere emphasizes friendship and fun, making it an entertaining watch for fans as they learn more about Vice's personality.