In "Palo The Leader Challenge," Vice Ganda engages in a fun and interactive game where participants showcase their leadership skills and creativity. The challenge typically involves various tasks or scenarios where each contestant must demonstrate how they would lead a group or tackle a problem. With Vice's signature humor and playful banter, the vlog captures moments of laughter, friendly competition, and unexpected twists. It highlights the importance of teamwork while showcasing Vice's ability to entertain and connect with his audience.