In the "Ang Iyo Ay Akin Challenge" with Vice Ganda, participants engage in a fun and competitive game inspired by the popular theme of claiming ownership or affection. The challenge likely includes humorous interactions, playful banter, and unexpected twists, showcasing Vice's signature comedic style. It's an entertaining blend of wit and charm as contestants navigate through various scenarios, all while emphasizing the lighthearted spirit of friendship and rivalry.