In the vlog "First to Make Baby Lakeisha SMILE Wins," Carlyn Ocampo and her friends or family engage in a playful challenge to see who can get baby Lakeisha to smile first. The video showcases a series of funny antics, silly faces, and creative strategies as everyone tries to elicit a giggle from her. Carlyn captures Lakeisha's adorable reactions and the lighthearted competition among the participants. The vlog emphasizes the joy of family bonding and the pure delight of seeing Lakeisha smile, creating a fun and heartwarming atmosphere throughout the challenge.