In the "Best Pranks 2020 | Never Grow Old" video, the vlogger showcases a compilation of the funniest and most creative pranks from the year. The video features a variety of setups, including playful interactions with friends, family, and unsuspecting strangers. Highlights include humorous situations that elicit genuine reactions, from confusion to laughter, as the vlogger pulls off clever tricks. The compilation captures the lighthearted spirit of the pranks and the joy of surprising people, emphasizing the vlogger's creativity and comedic timing. Overall, it's an entertaining recap that celebrates the best moments of prank culture in 2020, leaving viewers amused and excited for more antics.